Welcome to The First Descendant Python Build. This Python Build is updated for Season 3 Episode 2. The Python is a fast firing submachine gun that specializes in reducing the toxic and non-aatribute resistance of enemies.

Table of Contents:

You can also check out all our Weapon Builds and Character Builds Database if you are looking for more optimized builds. We also have a The First Descendant Character Tier List and a META Weapon Tier List if you wonder what to prioritize first.

TFD Wiki: We have expanded Alcasthq with tfd.gameslantern.com, a Wiki & Database for anything related to The First Descendant. Use the Character Editor or the Weapon Editor to theorycraft and create builds yourself. Browse Descendants, Weapons, Leaderboard Loadouts or use the Compare Tool. There are plenty of other features you can check out, too!


Python Summary

TFD Python Build Unique Ability Python Instinct

The Python is an Ultimate Submachine Gun. The Python is a specialized submachine gun invented to strategically utilize toxic Arche.

  • Name: Python
  • Type: Submachine Gun
  • Tier: Ultimate
  • Unique Ability: Python Instinct

Unique Ability “Python Instinct”

On hitting a Weak Point, inflicts the unique ability Prey on the target enemy.

Prey

Effect Level 0 Level 1 Level 2 Level 3 Level 4
Duration 1s 1.25s 1.5s 1.75s 2s
Max Stacks 20 22 24 26 28
Non-Attribute Resistance -2% -2% -2% -2% -2%
Toxin Resistance -3.6% -3.6% -3.6% -3.6% -3.6%
Non-Attribute Resistance per Stack -1% -1% -1% -1% -1%
Toxin Resistanc per Stack -1.3% -1.3% -1.3% -1.3% -1.3%

Base Weapon Stat Info

TFD Python Build Stats

Python Build for The First Descendant

Next, let us take a look at an optimized Python Build for The First Descendant. The Python weapon has a very high base fire rate. This weapon also has a high Multi-Hit base value, therefore building more into that makes sense!

Here is all the info you need to build a powerful Python:


Python Modules

TFD Python Build Module Setup

Modules are an important part of every weapon build in The First Descendant. For the Python we want to build out its high base Multi-Hit value by adding modules that boost Multi-Hit. Additionally, increasing the magazine size and just generally good mods increase the power tremendously.

General Python Module Configuration Table
Module Slot Module Name Socket Type
1 Multi-Percussion Sight Rutile Icon Rutile
2 Multi-Piercing Trigger Rutile Icon Rutile
3 Multi-Piercing Support Ammo Cerulean
4 Fire Rate Up Xantic
5 Charge Amplification Malachite
6 Expand Weapon Charge Cerulean
7 Action and Reaction Malachite
8 Rifling Reinforcement Malachite
9 Toxic Enhancement Rutile Icon Rutile
10 Poison Priority Rutile Icon Rutile

Weapon Readjustment

You can use the Weapon Readjustment at the Weapon Workbench in Albion. Here are the best Weapon Readjustments for the Python:

  • Multi-Hit Damage
  • Multi-Hit Chance
  • Firearm ATK
  • Rounds per Magazine

In any order. Try to upgrade the Weapon Readjustments to at least purple quality.


Weapon Cores

Weapon Cores juice up your damage quite tremendously. However, especially the later-level Weapon Cores are difficult to get. So start with whatever weapon cores you have available. Weapon Cores drop in the Void Erosion Purge endgame activity.

Higher level Weapon Cores drop in the higher level Void Erosion Purge levels in The First Descendant. However, you can gradually work towards the highest level. I recommend trying to get to level six as soon as possible, since it won’t require to clear many stages and will already increase the power of your weapon tremendously.

Best Weapon Cores for the Python:

  • Free Augmentation Icon TFDFire Rate (Free Augmentation)
  • Firepower Augmentation Icon TFDFirearm ATK (Firepower Augmentation)
  • Tactical Augmentation icon tfdFire Rate (Tactical Augmentation)
  • precision augmentation icon tfdSprint Speed or Grapple Hook (Precision Augmentation)
  • precision augmentation icon tfdSprint Speed or Grapple Hook (Precision Augmentation)

Alternatively, you could also go with 1x Fire Rate and 1x Toxic instead of 2x Fire Rate.


Python Lore Info

Python icon TFD

As the Magisters continued to research Arche, they also attempted to use related technologies to increase the Battle Power of the Descendants. The miniaturized Arche Control System was used in Modules, External Components, and Ultimate Weapons.

Code name “Python” was a piece of equipment invented to be compatible with toxic Arche. When the gun is fired, a small amount of toxic material is sprayed. The minute a bullet penetrates a target’s skin, a neurotoxin is released into their body.

However, because the emission of too much poison when loading the rounds into the weapon’s chamber can have a harmful effect on the user, a series of control procedures made it possible to safely and effectively use the powers of Arche. Thus, only Descendants who possess Arche abilities can use this weapon effectively.


Related Guides for The First Descendant

You can also check out our Ultimate Weapons Database for The First Descendant or the Builds Database for The First Descendant.