The Python Submachine Gun is one of the strongest weapon in The First Descendant. It sports an insane Fire Rate. The weapon works well on all builds, but especially fits Freyna’s Build.

To craft Python you have to to get the following four items crafted first:

  • Python Polymer Syncytium Blueprint
  • Python Synthetic Fiber Blueprint
  • Python Nano Tube Blueprint
  • Python Blueprint

Let’s take a look at the best farming locations for each item.

Python Polymer Synctium Blueprint

This is the first item required to create the Python. You’ll need the following items to make it:

  • 97x Hardener
    • Vespers Normal/Hard, Resource Boxes and Muntion.
  • 91x Nanopolymers
    • Agna Desert Normal/Hard, Resource Boxes and Muntion.
  • 11 Crystal Biogel
    • White-night Gulch Hard, Shipment Base: Vulgus Strategic Outpost. Item only drops from the BOSS MONSTER.
  • 1x Python Polymer Syncytium
    • Get Amorphous Material 029 from Agna Desert Normal, The Asylum. Then go kill Devourer for a chance to get the Blueprint.
    • Note: farm 10-20x Amorphous Material at once and then defeat Devourer until you run out of Amorphous Material. Drop chance of the item you want is low.

Python Synthetic Fiber Blueprint

  • 108x Silicon
    • Echo Swamp Normal/Hard, Resource Boxes and Munition
  • 73x Flectorite
    • White-night Gulch Normal/Hard, Resource Boxes and Munition
  • 10x Positive Ion Particle
    • Agna Desert Hard, Vermilion Waste area, Rock Cave Base Mission. Item only drops from the BOSS MONSTER.
  • 1x Python Synthetic Fiver
    • Get Amorphous Material 009 from Sterile Lands Normal, Restricted Zone area, The Forgottense mission. Then go kill Stunning Beauty on normal to open the Amorphous Material.
    • Note: Farm 10x Amorphous Material at once and then go defeat the Colossi to open up all of them.

Python Nano Tube Blueprint

  • 62x Monad Shard
    • Kingston Normal/Hard, Resource Boxes and Muntion.
  • 102x Ceramic Composite
    • White-night Gulch Normal/Hard, Resource Boxes and Muntion.
  • 8x Conductive Metallic Foil
    • This is a lot faster if you have Enzo.
    • With Enzo: Vespers Hard/Normal, open Encrypted Vaults
    • Without Enzo: Floodplain Extermination Mission, Vesper zone, hard difficulty
      • Drops from: Any mission monster, low drop chance
      • Amount: 1-4 materials per monster that drops any
  • 1x Python Nano Tube
    • Faster but harder: Farm Amorphous Material 059 in Kingston Hard, Slumber Valley Infiltration Mission Dungeon. Then go kill Executioner Colossi on hard for 32% chance to get the item.
    • Slower but easier: Farm Amorphous Material 039 in White-Night Gulch, Block Kuiper Mining defense mission. Then go kill Pyromaniac Colossi on normal for 15% chance to get the item.

Vespers Encrypted Vault locations:

Encrypted Vaults location in Vesper Zone The First Descendant

Python Blueprint

The Python Blueprint is the most annoying item out of all to get. However, with Sharen it’s a lot faster than without her, but still doable.

  • 1x Python Blueprint
    • With Sharen Infiltration: Vespers Hard, The Lumber Yard area, Culgus Strategic Outpost. Complete to get Amorphous Material 071 (5-25% drop chance).
    • Without Sharen: Farm Defend Albion Resource mission in Echo Swamp for Amorphous Material 025.
      • Amorphous Material 025: Defeat Dead Bridge on normal to open the Amorphous Material. Python Blueprint has a 6% drop chance.
How to farm Python Blueprint The First Descendant
Python Blueprint Open TFD

After that, you can craft the Python Submachine Gun. You will have to farm the Submachine Gun four more times if you want to max out its ability. Most items are fairly easy to get if you have Enzo and Sharen. If you don’t have them it will be a bit more tricky to get all materials, but not impossible!